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OMEGA-3

How is your Brain Function?

Your brain (and entire nervous system) consists of billions of single nerve cells (neurons). Each neuron is encased by a special membrane consisting of a bilayer of phospholipids. These phospholipids are critically important and have been found to be dysfunctional in disease conditions such as Alzheimer’s, autism, alcoholism, depression, schizophrenia, bipolar, and other pathologies. Critical fatty membrane components are the Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) with DocosaHexaenoic Acids (DHA) and EicosaPentaenoic Acids (EPA) being the most researched. Omega-3's are involved in multiple brain functions including membrane fluidity and permeability, signal transduction and neurotransmission. Since man cannot make Omega-3's, they must be gotten from his food - by eating safe, cold water oily fish (herring, salmon, tuna, mackerel, sardines, anchovies, trout) or by supplementation with safe fish oils (free of mercury, PCBs & heavy metals) or by consuming algae oil high in DHA and EPA. (DHA and EPA can also be made from Omega-3 Alpha-Linolenic Acid (ALA) obtained from plants (flax, chia, hemp), but this conversion is very limited in man). EPA serves as a precursor to DHA in the human biosynthetic pathway. Dietary DHA and EPA are transported in the blood via the lipoproteins and can traverse the Blood Brain Barrier (BBB). DHA concentrations are higher than EPA in the brain, eye, and sperm. DHA comprises about 30%-40% of the fatty acids in the gray matter of man's cerebral cortex and is highly concentrated in neuronal synaptic membranes. DHA is localized in the retinal membranes of the rod cells' photoreceptors and facilitates the visual conformational changes triggered by light during our vision. DHA also reduces cellular inflammation, improves immune function, optimizes cellular metabolism and energy production in mitochondria. The high concentration of Omega-3s within the inner membrane of the mitochondria allows for man's energy production and makes their peroxidation (degradation of lipids) perhaps the most dangerous of all oxidative stresses. Lipid peroxidation is one of the first and major outcomes in neurodegenerative diseases. We must protect our cell's membranes as they are the ultimate protector of human life. One method is to consume adequate amounts of Vitamin E, but the U.S. RDA is a paltry inadequate 15mg per day. Delta Tocotrienols, as in Delta-POWER™, are the first made and smallest of all natural vitamin E molecules allowing greatest mobility, easiest permeation and faster protection of our cellular membranes, as the best-in-class, fat-soluble antioxidant, and anti-inflammatory agents...


As man ages, Omega-3s and especially DHA decreases in man's fatty tissues and especially in the brain. Research reveals DHA to be deficient in the regions associated with Alzheimer's Disease. Brain atrophy (shrinkage) is the result of the structural and functional loss of neurons and their interconnections, which may be exhibited as White Matter Lesions (WMLs) in MRIs. Brain atrophy can be both local and/or general. As man ages, he can lose about 0.4% - 0.5% of his brain mass per year. By the age of 60, about 0.5% to 1% of brain volume can be lost per year. By the age of 75, man's brain can shrink and be 15% smaller on average than when he was younger. Older adults with these associated brain shrinkages can exhibit serious cognitive disorders and are at increased risk of dementia, Alzheimer's, ischemic stroke and vascular death. A wasting mind is a cruel death for both patient and caregivers. A landmark study found that aging humans who consumed more Omega-3s had increased gray matter brain volume! A recent follow-up study (March 2018) measured the "Omega-3 Index" in 2500 participants made up mostly of the offspring of the original Framingham study which began in 1948. The results amazingly revealed that those with the highest Omega-3 Index compared to the lowest had a 34% lower risk for death from any cause and a 39% lower risk for cardiovascular disease!! Another separate study involved the largest human clinical study using Tocotrienols for neuroprotection included 121 people over the age of 35 with Cardiovascular risk factors and White Matter Lesions. The results showed that Tocotrienols could attenuate the progression of White Matter Lesions in the human brain! (There was no increase in White Matter Lesions when Tocotrienols (200-400 mg/day) were taken over 1 and 2 years as measured by MRIs, whereas the controls all got worse!)

Besides evaluating subclinical markers for dementia by expensive MRI tests and/or by involved cognitive neuropsychological testing, there now exists a new, convenient and less expensive method to screen for brain cellular health. A simple test, using a drop of blood, can identify DHA and EPA fatty acids in your Red Blood Cells (RBCs) that are biomarkers of your body's Omega-3 status. (RBCs are advantageous because of their stability in blood with an average lifespan of 120 days which allows for a longer term assessment). These biomarkers, coupled with a Fifteen Minute Cognitive Assessment Test taken Online in your privacy, are used to identify nervous system deficiencies that may be inhibiting optimal cognitive performance. These assessments will provide suggested interventions that can help optimize memory, attention span, cognitive flexibility and mental processing.

For more information, please go to www.mybrainspan.com

If further interested in getting the Brain Assessment Kit, please go to the Order section of this website. (Be sure to include your Date of Birth, as your individual results will be compared to an International Database of similar individuals of your age and gender. Also clearly indicate your email address as we will send you the link to access the Cognitive Assessment Test.)


Reference For OMEGA-3

An Improvement of Cardiovascular Risk Factors by Omega-3 Polyunsaturated Fatty Acids (April 2018)
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Associations of Omega-3 Fatty Acid Supplement Use with Cardiovascular Disease Risks (March 2018)
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Erythrocyte Long-chain Omega-3 Fatty Acid Levels are Inversely Associated with Mortality and with Incident Cardiovascular Disease: The Framingham Heart Study (February 2018)
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The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Cardiometabolic Risk Factors: A Systematic Review. (February 2018)
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Association Between Blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents. (January 2016)
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Improved Framework for Tractography Reconstruction of the Optic Radiation (September 2015)
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Components of a Mediterranean Diet and Their Impact on Cognitive Functions in Aging (July 2015)
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Effects of Step-Wise Increases in Dietary Carbohydrate on Circulating Saturated Fatty Acids and Palmitoleic Acid in Adults with Metabolic Syndrome (November 2014)
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Connecting Leptin Signaling to Biological Function (October 2014)
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Omega-3 Fatty Acids Could Alleviate the Risks of Traumatic Brain Injury – A Mini Review (Apr-June 2014)
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Higher RBC EPA + DHA Corresponds with Larger Total Brain and Hippocampal Volumes WHIMS-MRI Study (February 2014)
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Influence of Omega-3 (N3) Index on Performance and Wellbeing in Young Adults After Heavy Eccentric Exercise (January 2014)
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Plasma Omega-3 PUFA and White Matter Mediated Executive Decline in Older Adults (2013)
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Low Blood Long Chain Omega-3 Fatty Acids in UK Children Are Associated with Poor Cognitive Performance and Behavior: A Cross-Sectional Analysis from the DOLAB Study (June 2013)
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DHA Supplementation Improved Both Memory and Reaction Time in Healthy Young Adults: A Randomized Controlled Trial (March 2013)
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Should Dietary SFA be Exchanged for Linoleic Acid? (October 2012)
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Red Blood Cell Omega-3 Fatty Acid Levels and Markers of Accelerated Brain Aging (February 2012)
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Are Omega-3 Fatty Acids Antidepressants or Just Mood-improving Agents? The Effect Depends Upon Diagnosis, Supplement Preparation, and Severity of Depression (letter) (January 2012)
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Dietary Supplementation with the Omega-3 Fatty Acid Docosahexaenoic Acid in Traumatic Brain Injury. (February 2011)
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Docosahexaenoic Acid Reduces Traumatic Axonal Injury in a Rodent Head Injury Model. (September 2010)
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